This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics. It combines the current state of knowledge in marine genomics and advanced natural products’ chemistry to pursue the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating effects. Further, it employs molecular-biology-based approaches and advanced chemical techniques to obtain and to select candidate compounds for pre-clinical and clinical studies.

35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters....Pages 1-34
Major Antimicrobial Representatives from Marine Sponges and/or Their Associated Bacteria....Pages 35-89
Discovery and Development of Novel Drugs....Pages 91-104
Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity....Pages 105-158
Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification....Pages 159-186
New Target Sites for Treatment of Osteoporosis....Pages 187-219
Biocalcite and Carbonic Acid Activators....Pages 221-257
Electrospinning of Bioactive Wound-Healing Nets....Pages 259-290
Entotheonella Bacteria as Source of Sponge-Derived Natural Products: Opportunities for Biotechnological Production....Pages 291-314